The NSs’ outer layer was coated with HA to improve biocompatibility and enable active targeting of tumor cells utilizing CD44+ upregulation on the cancer cell membranes.[107] The resulting Ti3C2Tx‐DOX exhibited notable drug loading capacity (up to 84.2%), remarkable biocompatibility, efficient pH‐responsiveness, and responsive drug release under NIR laser stimulation, as demonstrated by in vivo and in vitro experiments. The gene discussed is CD44; the disease is cancer.