Lysozyme, which is important in increasingthe body’s resistance,is of great importance in the diagnosis of many diseases such as infection,cold, bronchitis, asthma, leukemia, cancer, Crohn’s disease,and rheumatoid arthritis. In this study,Lyz-AuNP-MIP and AuNP-NIP SPR sensors containing lysozyme-specificrecognition sites were prepared for real-time determination of thelysozyme. This evidence concerns the gene LYZ and rheumatoid arthritis.