ROCK1 and Alzheimer disease: Our objective of this work is to accelerate the identificationof useful drugs for the treatment of AD based on drug repurposingthrough the identification of new ROCK inhibitors already in the market.In addition, we hope to characterize the pharmacophoric features necessaryfor designing potent ROCK1/2 inhibitors using ligand-based and structure-basedcomplementary strategies to help drug development within ROCK inhibitordiscovery projects.