Additionally, hypomethylationand PCNA mRNA levels have a reciprocal relationship (Figure e), underscoring the importanceof epigenetic control in modifying PCNA activity and tumor growth.More broadly, PCNA functions as a key platform for recruiting andcoordinating epigenetic modifiers, including DNA methyltransferasessuch as DNMT1. The gene discussed is PCNA; the disease is neoplasm.