Considering this perspective, the data inspectedusing GDSC and CTRP data set in GSCA across pan-cancer showed quitepromising results demonstrating increased mRNA levels of PCNA arerelated to increased drug sensitivity to therapeutic agents like Navitoclax,Ciclopirox, PIK-93 (Figure a,b) which primarily have pro-apoptotic, antifibrotic, PD-L1modulation, and antiproliferation properties.−,  Nonetheless,very few drug compounds displayed resistance to high PCNA expression,reflecting that PCNA-driven tumors might be exploiting alternativemechanisms to sustain. The gene discussed is PCNA; the disease is cancer.