During cancer development, resonanceenergy transfer (RET) leads to the irreversible activation of PKCδ.As a result, although retinoids can initiate the exergonic activationpathway, they are unable to engage the endergonic silencing pathway,leaving PKCδ locked in the active state and leading to the excessiveproduction of reactive oxygen species (ROS). This evidence concerns the gene PRKCD and cancer.