NS1 is a major virulence factor of influenza Aviruses, playing a key role in suppressing interferon expression andapoptosis in host cells.−, ,  TRIM25 is an E3 ubiquitin ligase that regulates viralRNA sensing and innate immune responses to infection.−, ,  The ability of NS1 to hijack TRIM25 contributes to viral evasionof host immunity., Understanding the molecular mechanismsby which NS1 selects between these binding targets is crucial forelucidating its immune evasion strategy. This evidence concerns the gene TRIM25 and infection.