In the colon organ, we observed that the antioxidant enzymes as CAT, SOD, and GPx activities were not significantly changed between CF and SDF rats (Fig. 2A, superior section); however, CAT (102.50 ± 15.56 nmol/mg protein/min), SOD (22.27 ± 2.70 U/mg protein), and GPx (158.20 ± 10.31 nmol/mg protein/min) in SDM rats were significantly higher than those of CM rats (Fig. 2A, inferior section). Here, SOD1 is linked to cystic fibrosis.