Notably, this elevated expression was substantially reduced following treatment with genipin, which has previously been documented to decrease levels of Akt/PKB in various cancer types, including osteosarcoma (Huang et al., 2023), oral squamous cell carcinoma (Wei et al., 2020), and bladder cancer (Li et al., 2018). Here, AKT1 is linked to oral cavity squamous cell carcinoma.