In colorectal cancer, NR1H4 activation suppresses the JAK2/STAT3 signaling pathway via trans-activation of the suppressor of cytokine signaling 3 (SOCS3) gene and antagonizes Wnt/β-Catenin signaling, acting as a tumor suppressor (Yu et al., 2020). The gene discussed is SOCS3; the disease is colorectal cancer.