CXCL8 and neoplasm: It has been observed that Hepatocyte Nuclear Factor-1β(HNF-1)βis preferentially activated in OCCC, leading o immunosuppression within the tumor microenvironment through activation of the Signal Transducer and Activator of Transcription 3 (STAT-3) signaling pathway and Nuclear Factor-κB (NF-κB) dependent pathway, resulting in the production of Interleukin-6 (IL-6) and Interleukin-8 (IL-8).