In summary, our study underscores the need for future interventional studies to elucidate the causal relationships between elevated hs-cTnT levels, diabetes mellitus, and adverse cardiovascular outcomes, while highlighting the importance of personalized post-PCI monitoring and management strategies in DM patients with elevated hs-cTnT levels to improve their long-term outcomes. The gene discussed is TNNT2; the disease is diabetes mellitus.