FH and age-related macular degeneration: However, studies have shown that the rs1061170 polymorphism (Tyr402His) in the FH gene, which is closely associated with an increased risk of AMD, does not directly affect the known Sia binding domain SCR20 but instead reduces the ability of FH to bind to retinal components, such as lipid peroxides and C-reactive protein (CRP; Molins et al., 2016; Romero-Vazquez et al., 2021; Giralt et al., 2024).