Notably, our model recapitulates altered expression of GWAS-validated AD risk genes, including MEF2C, OAS1, and SORL1 (Tansey et al., 2018; Salih et al., 2019; Miyashita et al., 2013), underscoring its translational relevance for probing AD pathophysiology. This evidence concerns the gene SORL1 and Alzheimer disease.