Notably, our model recapitulates altered expression of GWAS-validated AD risk genes, including MEF2C, OAS1, and SORL1 (Tansey et al., 2018; Salih et al., 2019; Miyashita et al., 2013), underscoring its translational relevance for probing AD pathophysiology. The gene discussed is MEF2C; the disease is Alzheimer disease.