The integration of our kinomic and transcriptomic data identified molecular hubs in the PI3K signaling pathway (PIK3R1, IGF1, AKT1) and inflammatory response pathway (IL6, JAK2, STAT3), which have been previously implicated in AD pathophysiology (Heneka et al., 2015; Calsolaro et al., 2016). Here, JAK2 is linked to Alzheimer disease.