AKT1 and Alzheimer disease: Our findings highlight several particularly promising therapeutic targets: the STAT3 signaling axis, which showed consistent dysregulation across multiple analytical modalities and central positioning in inflammatory networks; the PI3K/AKT pathway, which emerged as a critical hub in our network analysis with strong connections to both metabolism and inflammatory signaling; and specific kinases in the DYRK, GSK, and MAPK families that demonstrated altered activity in our kinomic analysis and have been previously implicated in neuroinflammatory processes in AD.