Treatment of the BBB spheroids with the CYP7B1 inhibitor, clotrimazole, yielded similar effects to treatment with CSF from patients with MS, that is downregulation of VE-cadherin, although this is most likely due to only trace expression of CYP7B1 in the human BBB cells (Caratis et al., 2025). Here, CYP7B1 is linked to myeloid sarcoma.