However, co-treatment of the spheroids with CSF from patients with MS and with either the EBI2 antagonist, NIBR189, or the CH25H inhibitor, desmosterol, rescued the CSF induced downregulation of VE-cadherin suggesting involvement of the EBI2/oxysterol system in VE-cadherin regulation during MS episode. The gene discussed is GPR183; the disease is myeloid sarcoma.