We therefore examined the chemotaxis and attachment of CD4+ T cells collected from the patients with MS to the BBB spheroids alone or in the presence of the EBI2/oxysterol compounds, the EBI2 antagonist NIBR189, the CH25H inhibitor desmosterol or the CYP7B1 inhibitor, clotrimazole (Fig. 4, Additional Fig. 5). This evidence concerns the gene GPR183 and myeloid sarcoma.