CYP7B1 and myeloid sarcoma: Co-treatment of the spheroids with the CSF from patients with MS and NIBR189, the EBI2 antagonist, or desmosterol, CH25H inhibitor, rescued the CSF induced downregulation of VE-cadherin. We also examined the expression of EBI2 and CH25H and CYP7B1 in the CSF treated spheroids and again found only HSD3B7 affected by the treatments (Fig. 3E).