Nowadays, 5-aminosalicylic acid, systemic corticosteroids, antibiotics (e.g. metronidazole, ciprofloxacin, and vancomycin), immunomodulators (azathioprine, 6- mercaptopurine, methotrexate, and cyclosporine), and infliximab, a TNF antagonist, are commonly used to treat of colitis (Jeong et al., 2019). This evidence concerns the gene TNF and colitis.