Aberrant expression of LAMP3 in SGECs can be induced by enhanced IFN‐I response, while LAMP3 promotes IFN‐I production through upregulation of ectopic TLR‐7, creating a positive feedback that maintains its misexpression and exacerbates the generation of IFN‐I in the SGs, which is crucial in the development of SS pathophysiology [113]. The gene discussed is TLR7; the disease is synovial sarcoma.