In this group of molecules, hsa‐miR‐145‐5p, shows decreased expression in SS, exhibits anti‐inflammatory properties and serves as a molecular link between IFN‐I and glandular dysfunction/inflammation by upregulating MUC1 and TLR4 Dysregulation of hsa‐miR‐145‐5p due to overactivation of the IFN‐I pathway results in heightened expression of MUC1 and TLR4, thereby driving the persistent progression of abnormal immune responses [164]. Here, TLR4 is linked to synovial sarcoma.