miR-223 may promote inflammation in JIA patients by enhancing the JAK/STAT signaling pathway, while miR-132 may reduce inflammation in JIA patients by inhibiting the JAK/STAT signaling pathway. Its inhibitory effect may be closely related to SOCS3 through the JAK/STAT signaling pathway. However, it is not yet understood how miR-223 and miR-132 interact with STAT3 and SOCS3 in the exosomes of JIA patients. Here, STAT3 is linked to juvenile idiopathic arthritis.