The G protein-coupled receptor 120 (GPR120), expressed in adipocytes, macrophages, podocytes, and enteroendocrine cells, has recently gained attention as a possible 'multisystem' modulator, influencing both lipid metabolism and inflammatory signaling [9]. The GPR120, a receptor involved in lipid sensing and anti-inflammatory signaling, may serve as a mechanistic link between dyslipidemia and renal injury in diabetes. The gene discussed is FFAR4; the disease is metabolic syndrome.