A strong positive correlation was observed between HDL-C and GPR-120 levels (Figure 1). Higher HDL-C levels are associated with increased GPR-120, suggesting that HDL-C might preserve or enhance GPR-120 function, potentially mitigating inflammation and metabolic disturbances in the DN patient group (p < 0.001 for both), highlighting substantial renal dysfunction. This evidence concerns the gene FFAR4 and liver dysplastic nodule.