MECP2 and Anxiety: Altered MeCP2 function in cholinergic (Zhou et al., 2017; Zhang et al., 2016), glutamatergic (Meng et al., 2016; Goffin et al., 2014) and GABAergic (Chao et al., 2010; Ure et al., 2016) neurons resulted in a variable pattern of changes in anxiety behaviour.