Choline supplementation in mice with specific loss of MeCP2 in excitatory neurons of the forebrain was associated with decreased anxiety and increased neurite length, number of dendritic branches and dendritic spine density, in the basal forebrain suggesting further molecular changes resulting from MeCP2 function in cholinergic neurons (Chin et al., 2019). This evidence concerns the gene MECP2 and Anxiety.