MeCP2 specifically affected the functioning of the cortico-LA pathway (not the thalamo-LA pathway) through effects on stabilisation of AMPA receptors and synaptic elimination and maturation, highlighting a potential mechanism of anxiety in Rett syndrome, since there is an overlap between fear and anxiety circuitry (Gambino et al., 2010). Here, MECP2 is linked to atypical Rett syndrome.