Furthermore, altered FKBP5 gene expression, which encodes a transcription factor that modulates GR function (Wochnik et al., 2005), has been identified in several animal models of psychiatric disorders, including depressive-like and PTSD-like models (van Doeselaar et al., 2023; Hä et al., 2021; van der Doelen et al., 2014; Criado-Marrero et al., 2017; Xu et al., 2017; Torrisi et al., 2021). This evidence concerns the gene NR3C1 and post-traumatic stress disorder.