BDNF and Anxiety: The WKY rat strain is characterized by elevated anxiety- and depressive-like behavior (Kaadt et al., 2021; McAuley et al., 2009), abnormalities in the monoamine system, glutamate and gamma-aminobutyric acid (GABA) malfunction, dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis, and attenuated serum and brain “Brain-derived neurotrophic factor” (BDNF) levels (Aleksandrova et al., 2019; Kyeremanteng et al., 2014).