Patients with RA have been found to have elevated levels of IL-8 in joint synovial fluid and the blood was assessed for the disease and joint damage severity.9 Along with a wide variety of immune mediators that have been found to be involved in RA, IL-8 and vitamin D have come to light as crucial with the prospects of influencing inflammation responses and dysregulated immunity. This evidence concerns the gene CXCL8 and rheumatoid arthritis.