CXCL8 and rheumatoid arthritis: The complicated interrelation of not only different immune mediators but also of numerous signaling pathways ensures that inflammation is self-maintained in RA.5 Of these mediators, IL-8 is the most powerful cytokine that plays the most important role during the inflammatory process in the synovial cavity.6 IL-8 is mainly released upon being activated by macrophages, fibroblasts, and endothelial cells in response to the inflammation trigger, and it acts through the production of neutrophils and their activation at sites of inflammation.7,8