IL-8, representing the family of cytokines with a proven pro-inflammatory potency, exhibits its effects by mediating the recruitment and activation of neutrophils in the synovial fluid, whereby inflammation is only amplified in RA patients.10,11 Besides its aggressive joint damaging effect, the prolonged inflammatory state plays a role in impairing overall health which makes RA chronic disability.12 This evidence concerns the gene CXCL8 and rheumatoid arthritis.