Previous studies have demonstrated that CAF has pro-cancer activity (Bussard et al., 2016), it promotes the growth, migration, and invasion of EC tumors by secreting pro-tumor factors, including IL-6, IL-8, matrix-derived factor-1 α, VEGF, etc., (Orimo et al., 2001; Matsubara and Bissell, 2016). This evidence concerns the gene VEGFA and neoplasm.