On the one hand, the interaction between SDF-1α and CXCR4 can remodel the basement membrane and degrade the basement membrane (Amine et al., 2009); On the other hand, in harmony with the degradation of the basement membrane, the RhoA/ROCK-mediated cascade can reorganize the actin cytoskeleton and activate the motility mechanism of tumor cells (Baiden-Amissah et al., 2021). The gene discussed is RHOA; the disease is neoplasm.