BRCA1 and breast carcinoma: Genetic mutations in BRCA1 are known to predispose to breast and ovarian cancer (Mota et al., 2023), as an important tumor suppressor gene, BRCA1 plays a key role in the occurrence and development of breast cancer and ovarian cancer, and BRCA1 protein is composed of multiple domains, among which the BRCT domain is its core component (Ismail et al., 2024).