RHOA and neoplasm: In addition, RhoA molecules localized to the cytoplasmic membrane are activated to signal ROCK and actomyosin to promote cell invasion (van Golen et al., 2002).In addition to this, Rho GTPase can also increase the production of angiogenesis, especially vascular endothelial growth factor (VEGF), which induces tumor angiogenesis and further promotes tumor cell metastasis (Saito et al., 2004).