MAPK8 and melanoma: In a lung metastasis model established through the tail vein injection of B16F10 melanoma cells in C57BL/6 mice showed that algal oil rich in n-3 polyunsaturated fatty acids effectively inhibits the metastatic outgrowth of melanoma cells by inactivating p38 MAPK and activating JNK1/2 to induce autophagy (Tan et al., 2018).