BECN1 and melanoma: In contrast to normal melanocytes, ERK1/2 activation in melanoma cells induces the autophagic degradation of MITF via Beclin-1/ATG12/LC3-II upregulation, leading to the downregulation of TYR and tyrosinase-related proteins (TRP) 1/2 and ultimately suppressing melanin production (Cho et al., 2017).