Compounds such as corilagin and cyanidin-3-O-glucoside stimulate Parkin-mediated mitophagy, mitigating NAFLD by inhibiting hepatic oxidative stress, NLRP3 inflammasomes, steatosis, and improving systemic glucose metabolism (Zhang et al., 2019; Li et al., 2020). This evidence concerns the gene PRKN and metabolic dysfunction-associated steatotic liver disease.