Therefore, p16 detection via immunohistochemical staining (p16-IHC) with FFPE tumour sections is recommended as a suitable surrogate parameter for HPV status in OPSCC in routine diagnostics according to the current edition of the TNM classification (AJCC 8th edition) and the CAP (College of American Pathologists) and ASCO (American Society of Clinical Oncology) guidelines [91], [92], [93]. Here, CDKN2A is linked to neoplasm.