TG and obesity due to melanocortin 4 receptor deficiency: The interplay between T2DM and thyroid dysfunction has been extensively studied since its initial documentation in 1979, revealing intriguing connections and mutual influences.4,5 Shared risk factors such as obesity underscore the complex relationship between these disorders, influencing disease onset and progression.6 Notably, thyroid hormones play pivotal roles in regulating glucose metabolism, suggesting that even subtle variations within normal thyroid hormone levels could predispose individuals to insulin resistance and T2DM, particularly in susceptible populations.7,8