The visceral adipose tissue is the main contributor to systemic inflammation in obesity, as it can produce and secrete a greater quantity of pro-inflammatory cytokines, such as leptin, adiponectin, interleukin 6, and tumor necrosis factor-α, which is compared to subcutaneous fat (38–40). The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.