Of all the intersecting genes, ZNF503 (57), S100A12 (57), RNASE1 (58), LHFPL3 (59), TRPM4 (60), and UCHL1 (61) have been confirmed to be associated with depression, and, among these six genes, only UCHL1 (62) and S100A12 (63) are involved in the progression of pulmonary fibrosis. This evidence concerns the gene RNASE1 and major depressive disorder.