In the context of BLM injury, the expression of IL-17A is upregulated, resulting in an increase in the expression of other pro-inflammatory cytokines such as TNF-α and chemokines such as IL-8 and CXCL5 in endothelial cells and epithelial cells, which further accelerating the formation of fibrosis (79). Here, CXCL5 is linked to Bloom syndrome.