TGFBR1 and Hepatic fibrosis: J-1155 and J-115, novel thiazole derivatives that selectively target and inhibit ALK5, effectively alleviate thioacetamide-induced liver fibrosis and associated inflammation in mice through dual inhibition of the TGF-β/Smad signaling pathway and blockade of the P2X7R-NLRP3 inflammasome axis (92).