High triglycerides can induce hepatocyte steatosis, inhibits HBsAg and HBV DNA secretion by inducing hepatocyte internal reticulum stress.Steatohepatitis due to intrahepatic lipid deposition has a negative effect on ISG expression and macrophage gene characteristics in the liver;may affect antiviral immune pathways, viral replication, and inflammatory responses.IFN-α can induce hepatic steatosis and promote a decrease in hepatitis B antigen by increasing triglyceride levels, the mechanism is not elucidated. The gene discussed is IFNA2; the disease is fatty liver disease.