CD4 and Alzheimer disease: As shown in Figure 4, the infiltration scores of activated CD8 T cell, CD56bright natural killer cell, CD56dim natural killer cell, central memory CD4 T cell, effector memory CD8 T cell, macrophage, monocyte, natural killer T cell, neutrophil, regulatory T cell, T follicular helper cell, and type 1 T helper cell, are significantly different between early- and adult-onset AD samples.