Box plots of the immune cell infiltration scores between AD samples and healthy controls were shown in Figure 3A, and the infiltration scores of activated CD4 T cell, activated CD8 T cell, effector memory CD8 T cell, macrophage, neutrophil, regulatory T cell, type 17 T helper cell and type 2 T helper cell were significantly higher in disease group than that in healthy controls. This evidence concerns the gene CD4 and Alzheimer disease.