Tn antigen-modified vaccines significantly inhibited tumor growth in MUC1 transgenic mice (287).Self-adjuvant glycopeptide vaccines (MUC1-Tn-Pam3CSK4) enhance immune responses via TLR2 agonists, inducing robust humoral and cellular immunity in tumor-bearing mice without the need for exogenous adjuvants (193). Here, TLR2 is linked to neoplasm.