Small molecule inhibitors (SMIs) have been designed to inhibit the ASPH enzymatic activity9 based on the catalytic site at the C-terminus of ASPH.24 ASPH inhibition reduced cell proliferation, migration, and invasion in various tumor cell lines, as well as tumor growth and metastasis in several animal models.9,16,17,24–27. The gene discussed is ASPH; the disease is neoplasm.