Western blot analysis also showed that the levels of total ubiquitin (Ub)-conjugated proteins, MAFbx, MuRF1, LC3b-II, and sXBP1 protein were significantly reduced in GA muscle of KPC tumor-bearing Xbp1mKO mice compared with corresponding Xbp1fl/fl mice (Fig. 4C, D). The gene discussed is TRIM63; the disease is neoplasm.