Independent qRT-PCR analysis further confirmed that mRNA levels of E3 ubiquitin ligases, MAFbx (gene name: Fbxo32) and MuRF1 (gene name: Trim63), autophagy markers, LC3b (gene name: Map1lc3b) and Beclin1 (gene name: Becn1) were significantly reduced in GA muscle of KPC tumor-bearing Xbp1mKO mice compared with KPC tumor-bearing Xbp1fl/fl mice (Fig. 4B). The gene discussed is BECN1; the disease is neoplasm.