Western blot analysis showed that KPC tumor-induced increase in the levels of total ubiquitinated proteins, MAFbx, MuRF1, ratio of LC3B-II/I, and p-STAT3 protein in skeletal muscle were significantly reduced in 4μ8C-treated mice compared to corresponding controls treated with vehicle alone (Fig. 8I, J). The gene discussed is STAT3; the disease is neoplasm.