RRM2 and amyotrophic lateral sclerosis: ALS/FTD-linked variants are typically found in the PrLD (e.g., G298S, Q331K, M337V, A382T, and I383V), but sometimes occur in RNA-recognition motif 1 (RRM1, as with P112H) or the linker between RRM1 and RRM2 (as with K181E)72.