In C. elegans, there are three RIG-I homologues, DRH-1, DRH-2 and DRH-3 (Guo et al., 2013), but DRH-1 appears to be functionally most similar to RIG-I in that it recognises viral RNAs and is essential for the intracellular pathogen response to viral infection (Sowa et al., 2020). This evidence concerns the gene RIGI and viral infectious disease.