Demographic and diagnostic variables including age at first AD was given (age), sex, Apolipoprotein E (APOE) genotype [18], Clinical diagnosis of cognitive status (dcfdx), Clinical consensus diagnosis of cognitive status at time of death (cogdx), Braak stage score (braaksc) [19], which is a semi-quantitative measure of neurofibrillary triangle pathology, CERAD score (ceradsc), which is a semi-quantitative measure of neuritic plaques were compared between the the two clusters. Here, APOE is linked to Alzheimer disease.