However, there were no significant difference between age at first Alzheimer’s dementia was given (p value= 0.6463), sex at birth(p value = 1), APOE genotype (p value = 0.7726), Clinical consensus diagnosis of cognitive status at time of death (p value = 0.08646), and Braak stage (p value=0.6157). The gene discussed is APOE; the disease is Alzheimer disease.