We observed increased abnormal nuclei morphology in both murine and human synucleinopathy tissue, suggesting a common phenotype between synucleinopathies and laminopathies (Fig. 2F, 3).Consistent with reports of α-syn induced nuclear damage in other synucleinopathy models and brain regions [35, 56], we report for the first time, to our knowledge, that cortical neurons in vivo and cultured Neuro 2a cells post α-syn corruption by PFFs have increased 53BP1 nuclear localization (Fig. 4A). This evidence concerns the gene TP53BP1 and laminopathy.