The abnormal nuclear morphological phenotypes we observed in synucleinopathy tissue from human and mouse closely resembles the morphological abnormalities observed in laminopathies, a group of disorders resulting from mutations in the LMNA and LMNB genes that encode the nuclear lamina proteins Lamin A/C and Lamin B respectively [8, 61]. This evidence concerns the gene LMNB1 and laminopathy.