For example, genomic and transcriptional analyses of cancer discovered that increased PHGDH expression promotes tumor growth (DeNicola, 2015; Locasale, 2011; Newman, 2017; Possemato, 2011) and provides a proliferative advantage in serine depleted tumor microenvironments (Ngo, 2020; Sullivan, 2019b). This evidence concerns the gene PHGDH and neoplasm.