Our CUT&RUN analysis found HF-Mrr1L1Q1*- bound DNA to be significantly enriched in the upstream intergenic regions of MDR1, CDR1 and FLU1 ORFs (Fig. 6C-E) with a peak profile identical to HF-Mrr1ancestral and HF-Mrr1Y813C. Here, CDR1 is linked to hydrops fetalis.