Postmortem findings of lower hypothalamic aromatase levels in men and women with MDD indirectly support the notion of altered aromatase activity (Wu et al., 2017) and aromatase gene polymorphisms being associated with depressive symptoms in women (Garcia‐Segura, 2008; Ancelin et al., 2020). The gene discussed is CYP19A1; the disease is major depressive disorder.