IFNA1 and neoplasm: demonstrated that IFN-α secreted by plasmacytoid dendritic cells (pDCs) promotes the generation of Schlafen 4-expressing myeloid derived suppressor cells (SLFN4+MDSCs), creating an immunosuppressive tumor microenvironment that facilitates intestinal metaplasia and gastric cancer transformation (Xiang et al., 2021); (2) Tomohiro et al.