This study indicates that Fx mitigates CCl4‐induced liver fibrosis in mice, likely via activation of the Nrf2/HO‐1/GPX4 axis and inhibition of ferroptosis, reflected by reduced hepatic iron overload, lipid peroxidation, and mitochondrial damage, alongside upregulated GPX4 expression (Figure 6). This evidence concerns the gene HMOX1 and Hepatic fibrosis.