The LASSO regression analysis showed that 5 CKD-related key genes (ARG1, LINC01361, PRO2958, SIK1, and TNFAIP6) and 5 HD-related key genes (PGLYRP1, SIK1, TNFAIP6, ZNF671, and ZNF750) were identified (Figures 3(D–G)). This evidence concerns the gene TNFAIP6 and chronic kidney disease.