Then, a total of 14 CKD- and HD-related intersection genes were obtained (Figure 3(C)), including TNFAIP6, PGLYRP1, ARG1, RPE, LHX6, ZNF750, LINC01361, PRO2958, CHST8, SIK1, ZNF671, FETUB, TRPV4, and DSG3. The gene discussed is SIK1; the disease is chronic kidney disease.