Interestingly, in line with our preclinical findings, an inverse correlation between baseline levels of SIRT1 and PCSK9 was observed (R = −0.1753, P = 0.0262) (see Supplementary material online, Figure S10A) which was particularly pronounced in patients with ST-elevation myocardial infarction (r = −0.2306, P = 0.0297). This evidence concerns the gene PCSK9 and ST Elevation Myocardial Infarction.