SIRT1 and Stroke: Among all patients, a total of 32 MACE (composite measure of non-fatal myocardial infarction, non-fatal stroke, ischaemia-driven revascularization, in-stent thrombosis, and death from cardiovascular causes) occurred during 1 year of follow-up, with Kaplan-Meier curves suggesting an inverse relationship between SIRT1 plasma levels and event-free survival (see Supplementary material online, Figure S10B).