In order to determine whether A2M‐AS1 is a crucial downstream gene regulated by p53 in PC cell migration and invasion, we conducted lentivirus‐mediated A2M‐AS1‐shRNA knockdown to reduce its expression in p53‐overexpressing cells, as well as induced endogenous expression of A2M‐AS1 in stable p53‐knockdown cells (Figure 4K,L). Here, TP53 is linked to pachyonychia congenita.