In our study we confirmed that Mar-2 is formed in the DSS-induced intestinal inflammation model but when we followed the kinetic of the pro-resolving metabolites NPD-1, Mar-2 and RvD5 during the time course of the disease (Fig. 6H–J) we found low colon levels in untreated mice of either genotype. This evidence concerns the gene SMPD1 and inflammatory response.