GSK3B and coronary artery disorder: Similarly, activity-suppressing phosphorylation of SERCA2A at serine 663 by glycogen synthase kinase 3 beta (GSK3β) reduces SERCA2 activity, leading to decreased Ca2+ uptake, cytosolic and mitochondrial Ca2+ overload, and increased cell death in ischemic heart disease and reperfusion injury (Gonnot et al., 2023).