The predominant misfolded proteins found in AD are amyloid-β (Aβ) and tau, in FTD tau and TAR DNA-binding protein 43 (TDP-43), in PD α-synuclein (α-syn), and in ALS TDP-43.74, 75, 76, 77, 78 Although in their native forms, these proteins differ considerably in size, subcellular localization, and function, they can all aggregate into large fibrils called amyloids. This evidence concerns the gene MAPT and Alzheimer disease.