,351,352 In line with this, selective 5-HT1AR blockade with NAD-299 had neuroprotective effects by reducing brain Aβ deposition, hippocampal neuronal loss, and oxidative stress, while simultaneously increasing hippocampal levels of brain-derived neurotrophic factor (BDNF) in an AD rat model.306. Here, BDNF is linked to Alzheimer disease.