HTR2A and amyotrophic lateral sclerosis: As the 5-HT2BR is critically involved in microglial function by regulating its motility, phagocytic activity, and release of endosomes,782,787 and deletion of the HTR2 gene exacerbated disease progression in a mouse model of ALS,731 activation of the 5-HT2BR has also been suggested as a potential strategy to modulate neuroinflammation in ALS.