Several 5-HT4R agonists, including RS-67333, VRX-03011, ML-10302, SSP-002392, prucalopride, renzapride, and usmarapride, are neuroprotective by increasing nonamyloidogenic sAPPα levels in vitro and in the cortex, hippocampus, and CSF of both WT rodents and several transgenic mouse models of AD.312. The gene discussed is HTR4; the disease is Alzheimer disease.