The inhibition of the RBM26-AS1 peptide impairs the proliferation ability of colon cancer cells.<h4>Conclusions</h4>A previously unknown micropeptide hidden in lncRNA RBM26-AS1 may contribute to colon cancer progression by enhancing nucleoplasmic transport and protein processing in the endoplasmic reticulum. The gene discussed is RBM26; the disease is malignant colon neoplasm.